Synthèse
Over the past few months, researchers have worked with Claude Science in beta for tasks like single-cell RNA sequencing analysis, CRISPR screen design, protein structure prediction, cheminformatics, and more. Manifold Bio designs tissue-targeting medicines—which home to a specific organ or cell type, so the drug acts where it’s needed and spares the rest of the body—and tests how millions of candidate binders corresponding to hundreds of targets distribute through a living body at once. Manifold
Over the past few months, researchers have worked with Claude Science in beta for tasks like single-cell RNA sequencing analysis, CRISPR screen design, protein structure prediction, cheminformatics, and more. Manifold Bio designs tissue-targeting medicines—which home to a specific organ or cell type, so the drug acts where it’s needed and spares the rest of the body—and tests how millions of candidate binders corresponding to hundreds of targets distribute through a living body at once. Manifold used Claude Science to nominate the targets for its latest experiments. For each tissue and target, Claude Science assessed surface expression, trafficking, and safety, ranking candidates against the criteria Manifold has learned from its own internal proprietary data. What set Claude Science apart from a general coding assistant, Manifold said, was that it could do this end-to-end, gathering the right data and applying the right judgment with the context of past programs built in.
Jérôme Lecoq, a neuroscientist at the Allen Institute, used Claude Science to build a multi-agent “computational review template” comprising about 20 custom skills geared towards writing long-form reviews. The sub-agents read through thousands of papers, pulling the central claim and the key quantitative finding, and storing them in an evidence state database. Then the pipeline constructs a narrative arc, writing the review section by section and delegating each to its own specialized sub-agent. Within each section, dedicated agents generate quantitative cross-study figures directly from the evidence database. A key component of the workflow, enabled by Claude Science, is the use of actor-critic pairs: one agent creates content while a separate reviewer agent evaluates it for accuracy and citation fidelity.
Before Claude Science, it could take Lecoq’s team as many as two years to write such a review.